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=Biomedical Engineering=
 
 
[[File:iis-project-image.png|thumb|right|450px]]
 
[[File:iis-project-image.png|thumb|right|450px]]
The world around us is getting a lot smarter quickly: virtually every single component of our daily living environment is being equipped with sensors, actuators, processing, and connection into a network that will soon count billions of nodes and trillions of sensors. These devices only interact with the human through the traditional input and output channels. Hence, they only indirectly communicate with our brain—through our five sense modalities—forming two separate computing systems: biological versus physical. It could be made a lot more effective if a direct high bandwidth link existed between the two systems, allowing them to truly collaborate with each other and to offer opportunities for enhanced functionality that would otherwise be hard to accomplish. The emergence of miniaturized sense, compute and actuate devices as well as interfaces that are form-fitted to the human body opens the door for a symbiotic convergence between biological function and physical computing.
 
  
Human Intranet is an open, scalable platform that seamlessly integrates an ever-increasing number of sensor, actuation, computation, storage, communication and energy nodes located on, in, or around the human body acting in symbiosis with the functions provided by the body itself. Human Intranet presents a system vision in which, for example, disease would be treated by chronically measuring biosignals deep in the body, or by providing targeted, therapeutic interventions that respond on demand and in situ. To gain a holistic view of a person’s health, these sensors and actuators must communicate and collaborate with each other. Most of such systems prototyped or envisioned today serve to address deficiencies in the human sensory or motor control systems due to birth defects, illnesses, or accidents (e.g., invasive brain-machine interfaces, cochlear implants, artificial retinas, etc.). While all these systems target defects, one can easily imagine that this could lead to many types of enhancement and/or enable direct interaction with the environment: to make us humans smarter!
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Research on biomedical sensing systems and signal processing algorithms has been very prolific in recent years with a variety of solutions in a wide range of application scenarios, for example long-term monitoring of human vital signs for disease detection. Low-power consumption and energy efficiency are the key features of such systems starting from the sensor node for data acquisition, towards embedded systems for data handling, and accurate algorithms for data processing.
  
Here, in our projects, we mainly focus on '''sensor, computation, communication, and emerging storage''' aspects to develop very efficient closed-loop sense-interpret-actuate systems, enabling distributed autonomous behavior.  
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Many research topics are actively ongoing around the human body, from chip design, to system development, to algorithmic investigations in various application scenarios. In the following sections you find links to past and current projects that you might find interesting.
  
<!--For example, to design the ''brain'' of our physical computing (i.e., the compute/interpret component), we rely on computing with ultra-wide words (e.g., 10,000 bits) that eases interfacing with various sensor modalities and actuators. This novel computing paradigm is called hyperdimensional (HD) computing that is inspired from the very size of the biological brain’s circuits: assuming 1 bit per synapse, the brain is made up of more than 24 billion of such ultra-wide words. You can watch some of our demos:
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Don't hesitate to drop us an email!
* [https://bwrc.eecs.berkeley.edu/sites/default/files/files/u2630/flexemg_v2_lq.mp4#t=2 Video1]
 
* [https://www.youtube.com/watch?time_continue=9&v=vTQGMQ6QaJE Video2]
 
* [https://iis-people.ee.ethz.ch/~arahimi/papers/ISSCC18-Demo.pdf PDF]
 
  
You can also find a collection of complemented projects with source codes/datasets here:
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=[http://iis-projects.ee.ethz.ch/index.php?title=Human_Intranet Human Intranet]=
* [https://github.com/HyperdimensionalComputing/collection Github link]
 
-->
 
==Prerequisites and Focus==
 
If you are an B.S. or M.S. student at the ETHZ, typically there is no prerequisite. You can come and talk to us and we adapt the projects based on your skills. The scope and focus of projects are wide. You can choose to work on:
 
  
<!-- * '''Efficient hardware architectures in emerging technologies''' (e.g., [https://www.zurich.ibm.com/sto/memory/ the IBM computational memory])-->
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Human Intranet is an open, scalable platform that seamlessly integrates an ever-increasing number of sensor, actuation, computation, storage, communication and energy nodes located on, in, or around the human body acting in symbiosis with the functions provided by the body itself. Human Intranet presents a system vision in which, for example, disease would be treated by chronically measuring biosignals deep in the body, or by providing targeted, therapeutic interventions that respond on demand and in situ.
* '''Exploring new Human Intranet/IoT applications'''
 
* '''Algorithm design and optimizations''' (Python)
 
* '''System-level design and testing''' (Altium, C-programming)
 
* '''Sensory interfaces''' (analog and digital)
 
  
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In the following, a summary of the main projects is given. More details can be found [http://iis-projects.ee.ethz.ch/index.php?title=Human_Intranet here].
  
<!-
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===Brain-Machine Interfaces===
* '''Theory''' of learning systems including HD computing, Hidden Markov Model (HMM), and clustering algorithms
 
Overall, our projects cover '''algorithmic, hardware/software, and system level''' design and developments.
 
However, if you have background in signal processing, VLSI or linear algebra is a super plus! -->
 
  
===Useful Reading===
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Noninvasive brain–machine interfaces (BMIs) and neuroprostheses aim to provide a communication and control channel based on the recognition of the subject’s intentions from spatiotemporal neural activity typically recorded by EEG electrodes.
*[https://ieeexplore.ieee.org/document/7030200/ The Human Intranet--Where Swarms and Humans Meet]
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*[https://link.springer.com/article/10.1007/s12559-009-9009-8 Hyperdimensional Computing: An Introduction to Computing in Distributed Representation with High-Dimensional Random Vectors]
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In this project, our goal is to develop efficient and fast learning algorithms that replace traditional signal processing and classification methods by directly operating with raw data from electrodes. Furthermore, we aim to efficiently deploy those algorithms on tightly resource-limited devices (e.g., Microcontroller units) for near sensor classification using artificial intelligence.
*[https://ieeexplore.ieee.org/document/8422472/ Hyperdimensional Modulation for Robust Low-Power Communications]
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*[https://iis-people.ee.ethz.ch/~arahimi/papers/TCAS17.pdf High-dimensional Computing as a Nanoscalable Paradigm]
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===Epilepsy Seizure Detection Device===
*[http://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780199794546.001.0001/acprof-9780199794546 How to Build a Brain]
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*[https://mitpress.mit.edu/books/sparse-distributed-memory Pentti Kanerva. 1988. Sparse Distributed Memory. MIT Press, Cambridge, MA, USA]
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Seizure detection systems hold promise for improving the quality of life for patients with epilepsy that afflicts nearly 1% of the world's population. In this project, our goal is to develop efficient techniques for EEG as well as non-EEG signals to detect an upcoming seizure in an ultra-low-power device.
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=[http://iis-projects.ee.ethz.ch/index.php?title=Digital_Medical_Ultrasound_Imaging Digital Medical Ultrasound Imaging]=
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[[File:US_probes.jpg|thumb|400px|Ultrasound Imaging Probes]]
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Ultrasound is one of the most used medical imaging modalities. Its main features are: real-time operation, low-cost, wide-availability, excellent spatial and time resolution, low-power. Recently, multiple innovative systems are being developed, targeting both high-end and wearable/embedded applications.
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At IIS, we are exploring the next generation of medical ultrasound imaging systems, spanning from very high-end systems (FPGA-based digital probes with >100 channels and ultra high-speed Gb/s interfaces), to wearable wireless systems (FPGA or MCU-based, equipped with WiFi or Bluetooth links).
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More information can be found [http://iis-projects.ee.ethz.ch/index.php?title=Digital_Medical_Ultrasound_Imaging here].
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=[http://iis-projects.ee.ethz.ch/index.php?title=Biomedical_System_on_Chips Biomedical System on Chips]=
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Every human and animal body generates a large and steady amount of data as consequence of several underlying life-long processes, e.g., respiration, vascular system dynamic, muscle contraction. By acquiring and processing these vital signals, usually by electrical or optical means, substantial amount of information can be extracted, enabling sense-making being used to take informative decisions. Successful application examples range from commercial fitness-tracker gadgets to medical-grade devices that enables tele-health remote medicine, as well as edge-cutting scientific research on living biological models.
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It is a joint effort between the Analog and Mixed Signal and Digital Design Groups. More info [http://iis-projects.ee.ethz.ch/index.php?title=Biomedical_System_on_Chips here].
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[[Category:Digital]]
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[[Category:Human Intranet]]
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[[Category:Semester Thesis]]
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[[Category:Master Thesis]]

Revision as of 15:22, 13 September 2022

Iis-project-image.png

Research on biomedical sensing systems and signal processing algorithms has been very prolific in recent years with a variety of solutions in a wide range of application scenarios, for example long-term monitoring of human vital signs for disease detection. Low-power consumption and energy efficiency are the key features of such systems starting from the sensor node for data acquisition, towards embedded systems for data handling, and accurate algorithms for data processing.

Many research topics are actively ongoing around the human body, from chip design, to system development, to algorithmic investigations in various application scenarios. In the following sections you find links to past and current projects that you might find interesting.

Don't hesitate to drop us an email!

Human Intranet

Human Intranet is an open, scalable platform that seamlessly integrates an ever-increasing number of sensor, actuation, computation, storage, communication and energy nodes located on, in, or around the human body acting in symbiosis with the functions provided by the body itself. Human Intranet presents a system vision in which, for example, disease would be treated by chronically measuring biosignals deep in the body, or by providing targeted, therapeutic interventions that respond on demand and in situ.

In the following, a summary of the main projects is given. More details can be found here.

Brain-Machine Interfaces

Noninvasive brain–machine interfaces (BMIs) and neuroprostheses aim to provide a communication and control channel based on the recognition of the subject’s intentions from spatiotemporal neural activity typically recorded by EEG electrodes.

In this project, our goal is to develop efficient and fast learning algorithms that replace traditional signal processing and classification methods by directly operating with raw data from electrodes. Furthermore, we aim to efficiently deploy those algorithms on tightly resource-limited devices (e.g., Microcontroller units) for near sensor classification using artificial intelligence.

Epilepsy Seizure Detection Device

Seizure detection systems hold promise for improving the quality of life for patients with epilepsy that afflicts nearly 1% of the world's population. In this project, our goal is to develop efficient techniques for EEG as well as non-EEG signals to detect an upcoming seizure in an ultra-low-power device.


Digital Medical Ultrasound Imaging

Ultrasound Imaging Probes

Ultrasound is one of the most used medical imaging modalities. Its main features are: real-time operation, low-cost, wide-availability, excellent spatial and time resolution, low-power. Recently, multiple innovative systems are being developed, targeting both high-end and wearable/embedded applications.

At IIS, we are exploring the next generation of medical ultrasound imaging systems, spanning from very high-end systems (FPGA-based digital probes with >100 channels and ultra high-speed Gb/s interfaces), to wearable wireless systems (FPGA or MCU-based, equipped with WiFi or Bluetooth links).

More information can be found here.

Biomedical System on Chips

Every human and animal body generates a large and steady amount of data as consequence of several underlying life-long processes, e.g., respiration, vascular system dynamic, muscle contraction. By acquiring and processing these vital signals, usually by electrical or optical means, substantial amount of information can be extracted, enabling sense-making being used to take informative decisions. Successful application examples range from commercial fitness-tracker gadgets to medical-grade devices that enables tele-health remote medicine, as well as edge-cutting scientific research on living biological models.

It is a joint effort between the Analog and Mixed Signal and Digital Design Groups. More info here.